You should be able to feel the difference if it is way out.
If it is too weak it will stall when you try to set off needing revs and clutch slipping to move off.
If it is too rich it will stutter when you are setting off.
The recommended way of setting the airscrew is to back off the cable so there is some slack, turn the tickover down a little on the other cylinder so that the cylinder you are adjusting is the strongest, then adjust the airscrew for a peak in the tickover.